GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs4409766 | 1 | rs11191425 | chr10:104625970 | SFXN2 | chr10:104474298-104498946:+ | -0.35 | -4.03 | 6.62E-5 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| BLCA | cis | rs12220777 | 1 | rs11201312 | chr10:81795778 | LOC219347 | chr10:81805991-81838949:- | 0.39 | 4.87 | 1.63E-6 | Chronic obstructive pulmonary disease-related biomarkers |
| BLCA | cis | rs12220777 | 1 | rs11201660 | chr10:81854531 | LOC219347 | chr10:81805991-81838949:- | -0.33 | -4.68 | 4.06E-6 | Chronic obstructive pulmonary disease-related biomarkers |
| BLCA | cis | rs12220777 | 1 | rs11201799 | chr10:81881954 | LOC219347 | chr10:81805991-81838949:- | -0.35 | -4.35 | 1.75E-5 | Chronic obstructive pulmonary disease-related biomarkers |
| BLCA | cis | rs12045807 | 1 | rs11204700 | chr1:150660702 | HORMAD1 | chr1:150670542-150693352:- | 0.38 | 3.98 | 8.24E-5 | Congenital left-sided heart lesions |
| BLCA | cis | rs11210359 | 1 | rs11210359 | chr1:74339167 | LRRIQ3 | chr1:74491704-74663871:- | 0.26 | 4.04 | 6.37E-5 | Bipolar disorder and schizophrenia |
| BLCA | cis | rs4660306 | 1 | rs11211132 | chr1:45990516 | CCDC163P | chr1:45960581-45965646:- | -0.79 | -16.21 | 2.35E-45 | Homocysteine levels |
| BLCA | cis | rs2275426 | 1 | rs11211199 | chr1:46287869 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -7 | 1.18E-11 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs11211208 | chr1:46334256 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -7.02 | 9.9E-12 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs11211230 | chr1:46406767 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -6.43 | 3.87E-10 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs11211234 | chr1:46438787 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -6.43 | 3.87E-10 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs11211241 | chr1:46452683 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -6.43 | 3.87E-10 | Body mass index |
| BLCA | cis | rs11211309 | 1 | rs11211309 | chr1:47045213 | CYP4A11 | chr1:47394848-47407156:- | 0.32 | 3.83 | 0.000151 | Schizophrenia |
| BLCA | cis | rs7112513 | 1 | rs11216316 | chr11:117081500 | PCSK7 | chr11:117075789-117102811:- | 0.37 | 4.65 | 4.59E-6 | Protein quantitative trait loci |
| BLCA | cis | rs3829251 | 1 | rs11233933 | chr11:71210070 | KRTAP5-10 | chr11:71276609-71277666:+ | 0.2 | 3.84 | 0.000145 | Vitamin D levels |